Setting out in April 1524, with a fleet of fourteen ships, Vasco da Gama took as his flagship the famous large carrack Santa Catarina do Monte Sinai on her last journey to India, along with two of his sons, Estêvão and Paulo.
After a troubled journey he arrived in India in September. Vasco da Gama immediately invoked his high viceregent powers to impose a new order in Portuguese India, replacing all the old officials with his own appointments. But Gama contracted malaria (mosquito-borne infectious), and died in the city of Cochin on Christmas Eve in 1524, three months after his arrival.
Vasco Da Gama was buried at the St Francis Church. At that time the church was called St Anthony’s. In 1538 Vasco Da Gama’s remains were taken first to Goa and then to Portugal.