It is located in an inaccessible cave, at the top of the Μount Kakavos at an altitude of about 250 meters and among imposing cliffs, a location that probably hosted an early Christian church and hermits during the Byzantine period.
The chapel is a remnant of one of the many metochions of the island, which came under the authority of Megistis Lavras Monastery in 1276.
Panagia was named Kakaviotissa after the Mount Kakavos, on which the chapel is located. It is open and celebrates every Tuesday after Easter, when the owners of the icon upload it to the church to be served. The chapel is the only roofless church in the world, which is built inside a cave.